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Advancing a targeted approach to the treatment of disorders involving NMDA receptor dysfunction including GRIN-related neurodevelopmental disorder (GRIN-NDD).

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About GRIN Therapeutics

Neurodevelopmental disorders represent significant areas of unmet need in healthcare. People affected by these disorders, predominantly children and young adults, can face a range of severe and devastating symptoms. In many cases, there are only limited or no treatments available. GRIN Therapeutics is dedicated to the research and development of precision therapeutics for pediatric neurodevelopmental disorders with the goal of bringing hope to patients and caregivers.

GRIN Therapeutics is advancing promising research and development to assess the safety and efficacy of the investigational therapy radiprodil for the treatment of serious neurodevelopmental disorders including GRIN-related neurodevelopmental disorder (GRIN-NDD), tuberous sclerosis complex (TSC), and focal cortical dysplasia (FCD).

In many cases, pediatric neurodevelopmental disorders are rare diseases that are not widely known or understood. In our effort to potentially bring new options to people living with pediatric neurodevelopmental disorders, GRIN Therapeutics is privileged to work with many of the global leaders in research, patient care, and advocacy to help build broader awareness of the impact of these disorders among patients, caregivers and communities.

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Our Science

Discover our clinical development program centered on our lead asset, radiprodil, and how it has the potential to make a difference in people living with rare, neurodevelopmental disorders with an underlying disease pathology involving dysregulated NMDA receptor activity.

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Disease State

NMDA receptor signaling is an essential component of establishing and maintaining excitatory/inhibitory balance in the brain and dysregulation of NMDA receptor activity may contribute to the underlying mechanisms of neurodevelopmental disorders.

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Featured News & Events

GRIN Therapeutics Announces First Patient Dosed in Global Phase 3 Beeline Trial of Investigational Radiprodil for GRIN-Related Neurodevelopmental Disorder

January 9, 2026 – GRIN Therapeutics, Inc. today announced that it has dosed the first patient in its global Phase 3 Beeline trial of investigational radiprodil in individuals with GRIN-related neurodevelopmental disorder (GRIN-NDD) with gain-of-function variants.

GRIN Therapeutics to Present on Global Phase 3 Beeline Clinical Trial of Radiprodil at American Epilepsy Society Annual Meeting

December 3, 2025 – GRIN Therapeutics, Inc. announced that it will present insights on the development of novel rating scales for GRIN-related neurodevelopmental disorder (GRIN-NDD) in a poster presentation at the American Epilepsy Society (AES) Annual Meeting being held December 5-9, 2025, in Atlanta, GA.

Neurvati Neurosciences Appoints Carlos Martin as Chief Commercial Officer

November 13, 2025 – Neurvati Neurosciences, the neuroscience development platform of Blackstone Life Sciences, today announced the appointment of Carlos Martin as Chief Commercial Officer (CCO).